Researchers from the Institute for Molecular Bioscience have been awarded worldwide funding to fight an anticipated escalation of pores and skin most cancers circumstances in US troops who served in Iraq and Afghanistan.
Dr Samantha Stehbens and Dr Mel White will spend three years combining their work in most cancers biology and neuroscience after receiving a United States Department of Defense Melanoma Research Program Idea Award.
An rising drawback for returning US troops
“Only 13 per cent of the 3 million US defence staff deployed in Iraq during the Operation Iraqi Freedom missions wore sunscreen, so the rate of melanoma in returned troops is increasing,” Dr Stehbens mentioned.
“Melanoma is often fatal because it is particularly efficient at travelling to the brain and thriving once it gets there.
“Unfortunately, once it reaches the brain it becomes increasingly difficult to treat, with a median overall survival of just 5 to 11 months.”
Melanoma thrives within the mind
Melanoma is the commonest most cancers identified in Australians aged 25-29 years, so the researchers say their work may also have native advantages.
The undertaking is ways to cease melanoma progressing to the mind and the way the mind setting can have an effect on the seeding of tumours.
“Understanding how melanoma cells react in the soft tissue of the brain is crucial to treating this disease,” Dr White mentioned.
New strategies to perceive melanoma within the mind
“We have built models in our labs to help us understand what happens to melanoma cells in response to different therapies.
“One model is a brain-on-a-chip device where we can grow tumour cells in the presence of blood vessels and brain tissue scaffolds.
“We have also established a new pre-clinical model at UQ using transgenic quails to examine how melanoma cells behave in a neural like environment.”
A group of consultants with new concepts
The UQ researchers have established an interdisciplinary group with experience in most cancers biology, neuroscience, vascular biology, scientific radiation oncology, physics and supplies chemistry to assist them handle issues that may’t be tackled by a person laboratory.
The group contains Professor Alan Rowan from UQ’s Australian Institute for Bioengineering and Nanotechnology, Professor Paul Timpson from the Garvan Institute of Medical Research, Dr Anne Lagendijk from UQ’s Institute for Molecular Bioscience and Associate Professor Mark Pinkham from UQ and the Princess Alexandra Hospital’s Gamma Knife® Centre of Queensland.
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